There was no difference in the time to extubation, incidence of PONV, or sore-throat between the two groups ( Table 2).
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Similarly, there was a significant difference in the skin incision response, with a more positive response to skin incision seen in the saline group ( Table 2). The induction dose of propofol, consumption of intraoperative fentanyl, and the mean isoflurane requirements were significantly less in the dexmedetomidine group versus the saline group ( Table 2). However, there was no significant difference in the SBP response between the two groups (P = 0.904, Fig. After laryngoscopy and intubation, linear mixed effect modelling showed a significantly lower trend of increase in HR in the dexmedetomidine group versus the saline group (P = 0.012, Fig. The peripheral oxygen saturation and sedation scores (modified observer’s assessment of alertness/sedation scale) were also recorded before and after nebulization for each patient.įollowing nebulization, there were no differences in the pre-induction hemodynamics or sedation scores between the two groups. The time to extubation in minutes (from administration of neostigmine to removal of the tracheal tube) was noted in both the groups. If a positive response to skin incision was present, inj.
The response to skin incision was noted and recorded as a binary ‘yes/no response’ (no, if 20% changes in HR and/or SBP). The induction dose of propofol, total dose of intraoperative fentanyl and mean minimum alveolar concentration (MAC) of isoflurane were recorded for each patient. BP measurements were performed at the same time points as the HR. The secondary aim was to study the non-invasive SBP changes following laryngoscopy and intubation, intraoperative anesthetic and analgesic consumption, time to extubation, and the 2-h incidence of PONV and sore-throat.
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